OperonDB: a comprehensive database of predicted operons in microbial genomes
نویسندگان
چکیده
The fast pace of bacterial genome sequencing and the resulting dependence on highly automated annotation methods has driven the development of many genome-wide analysis tools. OperonDB, first released in 2001, is a database containing the results of a computational algorithm for locating operon structures in microbial genomes. OperonDB has grown from 34 genomes in its initial release to more than 500 genomes today. In addition to increasing the size of the database, we have re-designed our operon finding algorithm and improved its accuracy. The new database is updated regularly as additional genomes become available in public archives. OperonDB can be accessed at: http://operondb.cbcb.umd.edu.
منابع مشابه
DOOR: a database for prokaryotic operons
We present a database DOOR (Database for prOkaryotic OpeRons) containing computationally predicted operons of all the sequenced prokaryotic genomes. All the operons in DOOR are predicted using our own prediction program, which was ranked to be the best among 14 operon prediction programs by a recent independent review. Currently, the DOOR database contains operons for 675 prokaryotic genomes, a...
متن کاملComputational identification of operons in microbial genomes.
By applying graph representations to biochemical pathways, a new computational pipeline is proposed to find potential operons in microbial genomes. The algorithm relies on the fact that enzyme genes in operons tend to catalyze successive reactions in metabolic pathways. We applied this algorithm to 42 microbial genomes to identify putative operon structures. The predicted operons from Escherich...
متن کاملMicrobial computational genomics of gene regulation*
Escherichia coli is a free-living bacterium that condensates a large legacy of knowledge as a result of years of experimental work in molecular biology. It represents a point of departure for analyses and comparisons with the ever-increasing number of finished microbial genomes. For years, we have been gathering knowledge from the literature on transcriptional regulation and operon organization...
متن کاملOperomeDB: A Database of Condition-Specific Transcription Units in Prokaryotic Genomes
Background. In prokaryotic organisms, a substantial fraction of adjacent genes are organized into operons-codirectionally organized genes in prokaryotic genomes with the presence of a common promoter and terminator. Although several available operon databases provide information with varying levels of reliability, very few resources provide experimentally supported results. Therefore, we believ...
متن کاملAutomatic Annotation of Microbial Genomes and Metagenomic Sequences
We have developed Fgenesb_annotator pipeline that provides completely automatic and comprehensive annotation of microbial genomic sequence. The pipeline identifies protein, tRNA and rRNA genes, finds potential promoters, terminators and operons. Finally potential functions are assigned to predicted proteins using comparison with a set of databases such as COG, KEGG and NR. The package provides ...
متن کامل